Human Papillomavirus Vaccine

Nasal vaccination with HPV-like particles affects trachea and lungs

Published in Vaccine Weekly, January 29th, 2003

According to recent research from Switzerland, investigators found "Vaccination by the nasal route has been successfully used for the induction of immune responses. Either the nasal-associated lymphoid tissue (NALT), the bronchus-associated lymphoid tissue, or lung dendritic cells have been mainly involved.

"Following nasal vaccination of mice with human papillomavirus type 16 (HPV16) virus-like-particles (VLPs), we have previously shown that interaction of the antigen with the lower respiratory tract was necessary to induce high titers of neutralizing antibodies in genital secretions."

"However, following a parenteral priming, nasal vaccination...

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Source: Vaccine Weekly (2003-01-29)

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