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Autoimmune Disease Vaccine

Antibody prevents autoimmune encephalomyelitis in common marmosets

Published in Vaccine Weekly, January 29th, 2003

A monoclonal antibody against interleukin-12p40 (IL-12p40) prevented neural damage in a marmoset model of multiple sclerosis, according to a report from researchers in the Netherlands.

"The experimental autoimmune encephalomyelitis (EAE) model in the common marmoset approximates recognized features of the human disease multiple sclerosis (MS) with regard to its clinical presentation as well as neuropathological and radiological aspects of the lesions in brain and spinal cord" said Herbert P. M. Brok and colleagues at the Biomedical Primate Research Center in Rijswijk.

They continuted, "IL-12 is a proinflammatory cytokine that is produced by APC and...

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