Cancer Vaccine
Dendritic cells generated by Flt3L or GM-CSF/IL-4 generate antileukemia response
Published in Vaccine Weekly, January 29th, 2003
"Bone marrow (BM)-derived dendritic cells (DCs) cultured in granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin 4 (1L-4) have been used to generate antitumor immune responses. The cytokine Flt3 ligand (Flt3L) also has been shown to generate BM DCs. We sought to determine if DCs generated by using Flt3L then matured with lipopolysaccharide (LPS) could lead to DCs with in vivo antiacute myelogenous leukemia (anti-AML) activity," researchers in the United States report.
"LIPS and tumor necrosis factor alpha (TNF-alpha) are effective agents for maturing DCs; however, they have potential in vivo toxicities," wrote Brenda J. Weigel and colleagues at...
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Source: Vaccine Weekly (2003-01-29)
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