Immunology
Nippostrongylus brasiliensis induces antigen-specific immune response
Published in Vaccine Weekly, February 12th, 2003
According to recent research from the United States, "Th2 immune responses to a number of infectious pathogens are dependent on B7-1/B7-2 costimulatory molecule interactions. We have now examined the Th2 immune response to Nippostrongylus brasiliensis (Nb) in B7-1/B7-2(-/-) mice and show that Th2 effector cells develop that can mediate worm expulsion and produce substantial Th2 cytokines comparable with wild-type infected mice; however, in marked contrast, B cell antigen-specific antibody production is abrogated after 137 blockade."
"To examine the mechanism of T cell activation, OVA-specific DO11.10 T cells were transferred to recipient mice, which were then...
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Source: Vaccine Weekly (2003-02-12)
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