HIV/AIDS Vaccine

Adenovirus vectors effectively deliver MHC class I and II antigens

Published in Vaccine Weekly, February 12th, 2003

"Dendritic cells (DCs) are highly specialised antigen-presenting cells (APCs) that are essential for the initiation and modulation of T cell-mediated immune responses," according to recent research from England. "In order to induce effective CTL responses against most infections and tumors, DCs must prime both CD4+ and CD8+ antigen-specific T cells."

"It is, therefore, important in vaccine design to produce antigen-delivery systems that lead to the simultaneous presentation of multiple histocompatibility complex (MHC) class I- and class II-restricted antigenic peptides by DCs," explained O. B. Herrera and coauthors, University of London Imperial College of Science,...

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Source: Vaccine Weekly (2003-02-12)

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