DNA Vaccine

Immune evasion gene allows tumor cells to escape attack by cytotoxic T cells

Published in Vaccine Weekly, February 19th, 2003

According to a study from England, "DNA vaccines induce cytotoxic T lymphocyte (CTL) attack on target tumor epitopes, but tumor elimination in vivo also requires sufficient effector CTL to enter the site, guided by inflammatory chemokines.

"Many herpesviruses contain genes for chemokine and chemokine receptor-like proteins to protect infected cells from immune attack. To assess if this evasion strategy could protect tumor cells, we used a model where CTL specific for a single epitope were the only effectors."

"Following DNA vaccination, CTL eliminated tumor cells from a subcutaneous site," reported J. Rice and colleagues at Southampton University...

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Source: Vaccine Weekly (2003-02-19)

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