Cancer Vaccine
Researchers discuss rationale for use of non-live vectors in cancer vaccines
Published in Vaccine Weekly, February 26th, 2003
According to recent research from France, "Different arguments suggest that cytotoxic CD8 T lymphocytes (CTL) play a key role in the protection against tumors and in the establishment of anti-tumor immunity. Unfortunately, administration of soluble proteins alone generally does not induce CD8+ T cells presumably because antigen derived peptides are not introduced into the major histocompatibility complex (MHC) class I antigen presentation pathway.
"Attenuated recombinant live vectors such as viruses or bacteria which have the ability to deliver antigen into the cytosol of cells have been shown to induce cytotoxic T cell response."
"However, there...
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Source: Vaccine Weekly (2003-02-26)
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