HIV/AIDS Vaccine

Viral evolution and challenges in the development of HIV vaccines outlined

Published in Vaccine Weekly, February 26th, 2003

According to a study from the United States, "Potent virus-specific cytotoxic T lymphocyte (CTL) responses elicited by candidate AIDS vaccines have been shown to provide short-term control of viral replication following pathogenic viral challenges in rhesus monkeys. We have recently shown that vaccines that control rather than prevent immunodeficiency virus infections are still subject to immune escape."

"In particular, viral mutations can develop that result in viral escape from recognition by immunodominant CTL, loss of immune control of viral replication, and clinical disease progression," reported Dan H. Barouch and Norman L. Letvin at Beth Israel Deaconess Medical...

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Source: Vaccine Weekly (2003-02-26)

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