HIV/AIDS Vaccine

SIV macaque model useful for developing treatment strategies for HIV-1 in humans

Published in Vaccine Weekly, February 26th, 2003

According to recent research from the United States, "Studies in the SIVmac macaque model have demonstrated that the extent of virus-specific CD4+ and CD8+ T-cell responses induced by vaccination prior to virus-challenge exposure correlate with viremia containment following establishment of infection."

"These findings led to the hypothesis that active immunization with vaccines able to induce virus-specific T-cell responses following the establishment of infection could also ameliorate the virological outcome," said Genoveffa Franchini and colleagues at the National Cancer Institute in Bethesda, Maryland. "Here, we will review the relative effect of ART and vaccination...

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Source: Vaccine Weekly (2003-02-26)

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