Alzheimer Disease
Agents that target beta-amyloid show promise against Alzheimer's Disease
Published in Vaccine Weekly, March 5th, 2003
"Plaques containing beta-amyloid (A-beta) peptides are one of the pathological features of Alzheimer's disease, and the reduction of A-beta is considered a primary therapeutic target. Amyloid clearance by anti-A-beta antibodies has been reported after immunization, and recent data have shown that the antibodies may act as a peripheral sink for A-beta, thus altering the periphery/brain dynamics," researchers in the United States report.
"Here we show that peripheral treatment with an agent that has high affinity for A-beta (gelsolin or GM1) but that is unrelated to an antibody or immune modulator reduced the level of A-beta in the brain, most likely because of a...
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Source: Vaccine Weekly (2003-03-05)
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