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Vaccine Development

CD40, B7, and major histocompatibility complex enhance immunity

Published in Vaccine Weekly, April 2nd, 2003

CD40, B7, and the major histocompatibility complex play roles in the induction of enhanced immunity by cryptococcal polysaccharide-pulsed antigen-presenting cells.

"Immunization of mice with activated antigen-presenting cells (APC) pulsed ex vivo with cryptococcal capsular polysaccharide, a glucuronoxylomannan (GXM-APC) results in prolongation of survival and delayed-type hypersensitivity (DTH) responsiveness following infection with Cryptococcus neoformans (NU-2)," researchers in the United States report.

"GXM-APC has both nonspecific and GXM-specific effects that influence the immune responses that develop in mice after infection with NU-2,"...

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