Immunology

Understanding mucosal immunity may lead to new vaccines

Published in Vaccine Weekly, April 16th, 2003

Local mucosal immunization leads to antigen-specific IgA production at distant mucosal sites, presumably through the migration of activated B cells. Because of the important implications for vaccine development, Eric Kunkel and colleagues are working to understand the mechanisms of IgA-secreting B cell trafficking between distant mucosal sites.

Having previously identified a chemokine called MEC, which is expressed by epithelial cells in a variety of mucosal tissues, they report now, in the April 2003 Journal of Clinical Investigation, that the MEC-binding chemokine receptor CCR10 is expressed on IgA-secreting B cells.

This suggests that...

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Source: Vaccine Weekly (2003-04-16)

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