Allergy Vaccines
Pre-pro sequence needed for DNA vaccine to induce dust mite allergen antibodies
Published in Vaccine Weekly, April 16th, 2003
"The mite protein Der p 1 is a major trigger of allergy and atopic asthma worldwide, and thus, a good vaccine candidate for allergy prevention. Since it is a cysteine protease, the catalytic effects of Der p 1 vaccination may be unpredictable. One approach to reduce this risk is to vaccinate with DNA encoding enzymatically inactive forms of Der p 1," said C.B. Wolfowicz and colleagues.
In their study, "... Der p 1 DNA without its native pre-pro sequences potently induced Der p 1-specific...
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Source: Vaccine Weekly (2003-04-16)
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