Melanoma

Suppressor lymphocytes may modify T-cell response to anti-tumor immunization

Published in Vaccine Weekly, April 16th, 2003

CD4+CD25+ suppressor lymphocytes may modify the T-cell response of melanoma patients' T-cell response undergoing tumor antigen immunization, according to a study by U.S. National Institutes of Health scientists.

"Murine studies have suggested that a population of CD4+ T cells expressing the alpha chain of the interleukin (IL)-2 receptor (CD25+) are phenotypically anergic in response to T-cell receptor stimulation and can suppress the function of CD4+ and CD8+ T cells. Recent studies of peripheral lymphocytes from healthy human volunteers have identified a similar population, although little is known about the presence and activity of these cells in patients with cancer...

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Source: Vaccine Weekly (2003-04-16)

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