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Botulism

Vaccination with botulinum toxin fragment protects against poisoning

Published in Vaccine Weekly, April 30th, 2003

Vaccination with botulinum toxin fragment protects against poisoning

"Botulinum toxin is the etiologic agent responsible for the disease botulism, which is characterized by peripheral neuromuscular blockade. Botulism is ordinarily encountered as a form of oral poisoning. The toxin is absorbed from the lumen of the gut to reach the general circulation and is then distributed to peripheral cholinergic nerve endings," scientists in the United States report.

"However, there is a widespread presumption that botulinum toxin can also act as an inhalation poison, which would require that it be absorbed from the airway," said Jong-Beak Park and Lance L....

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