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Smallpox Vaccine

Progressive vaccinia more likely in patients with cell-mediated immunodeficiency

Published in Vaccine Weekly, April 30th, 2003

Among patients with immune disorders, including AIDS, progressive vaccinia is more likely in those with cell-mediated immunodeficiency.

"The resumption of smallpox vaccination for health care workers and other first responders has raised concern about the occurrence of complications in people with immunodeficiency disorders, including those infected with human immunodeficiency virus. During the era of universal vaccination, roughly one person per million vaccinees in the general population developed progressive vaccinia, which is characterized by the relentless outward spread of infection from the vaccination site and eventual dissemination to other areas on the body,"...

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