Cancer Vaccine

CD4+ cells play critical role in tumor immunity against simian virus 40 antigen

Published in Vaccine Weekly, May 7th, 2003

CD4+ T lymphocytes played a critical role in antibody production and tumor immunity against simian virus 40 large tumor antigen.

According to recent research published in the journal Cancer Research, "The role of CD4+ T lymphocytes in antitumor immunity has been largely attributed to providing signals required for the priming of MHC class I-restricted CD8+ cytotoxic T lymphocytes, and CD8+ cytotoxic T lymphocytes are thought to serve as the predominant mediators of tumor killing in vivo. We decided to evaluate the role of T lymphocyte subsets in tumor immunity induced by recombinant SV40 large tumor antigen (Tag) within an experimental murine pulmonary metastasis...

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Source: Vaccine Weekly (2003-05-07)

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