Published in Vaccine Weekly, May 7th, 2003
"Mast cells (MCs) are considered major players in IgE-mediated allergic responses, but have also recently been recognized as active participants in innate as well as specific immune responses. Recent work provided evidence that MCs are able to activate B and T lymphocytes through the release of vesicles called exosomes. Here we demonstrate that exosomes, which are located in the endocytic pathway, harbor exogenous antigens that associate with other molecules endowed with immunomodulatory functions, including 60- and 70-kDa heat shock...
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