Immunology

CIR-T cells mediate anti-HIV-1 activity, bypassing class I requirements

Published in Vaccine Weekly, May 21st, 2003

Chimeric immune T-cell receptor cells "can mediate antiviral activity against HIV-1 in cells that are resistant to class I-restricted CTL-mediated activity" and also suppress the virus in several cell types, report infectious disease specialists at the University of California, Los Angeles.

"Transduction of T cells with a chimeric immune T-cell receptor (CIR) has been proposed as a strategy to generate cellular immunity against viral pathogens such as HIV-1. In the case of the CD4-CD3-zeta chain (CD4-zeta) CIR, specificity for HIV-1 is conferred by binding of the CD4 moiety to gp120 on the surface of infected cells. However, it is unclear whether CD4-zeta-T cells may...

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Source: Vaccine Weekly (2003-05-21)

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