Hepatitis B Vaccine
Infection in kidney transplant patient caused by novel mutants of hepatitis B
Published in Vaccine Weekly, June 4th, 2003
"A renal transplant recipient became persistently positive for hepatitis B virus (HBV) despite pre-existing anti-hepatitis B surface (HBs) antibodies," researchers in Germany report.
"The antigenicity and immunogenicity of wild-type (wt) and mutant HBs antigens (Ags) were compared," stated Mengji G. Lu and Thomas Lorentz at the Universitatsklinikum Essen. "In contrast to wt HBsAg, genetic vaccination with mutant HBsAgs did not induce anti-HBs. Thus, mutations within HBsAg may enable HBV to escape...
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Source: Vaccine Weekly (2003-06-04)
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