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Hepatitis A Vaccine

Vaccination against hepatitis A elicits humoral and cellular immune responses

Published in Vaccine Weekly, June 4th, 2003

by Maria G. Essig, MS, ELS, senior medical writer - Vaccination against hepatitis A stimulates release of both interferon-gamma and interleukin-10, according to a report in Pharmacotherapy.

Mary S. Hayney and colleagues at the University of Wisconsin in the United States evaluated cytokine production in 25 healthy adults immunized with an inactivated hepatitis A vaccine. Levels of interferon-gamma (IFN-gamma) and interleukin-10 (IL-10) were measured in sera on the day of vaccination and 2, 5, 7, 10, and 28 days afterward.

"Production of IFN-gamma and IL-10 by peripheral blood mononuclear cells stimulated in culture with hepatitis A virus was...

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