HIV/AIDS Vaccine

DNA priming improves HSV-1 amplicon vector immunogenicity

Published in Vaccine Weekly, June 11th, 2003

by Michael Greer, senior medical writer - DNA priming improves the immunogenicity of herpes simplex virus-based vectors expressing HIV proteins, researchers in the United States report.

"A single inoculation of herpes simplex virus type-1 (HSV-1) amplicon vectors encoding human immunodeficiency virus type-1 gp120 (HSV:gp120) results in robust, specific immune responses to gp120," explained Xiuqing Wang and colleagues at the University of Rochester Medical Center in Rochester, New York and the University of California at Davis.

These vaccines work even better as part of a prime-boost regimen including gp120 plasmid DNA, Wang and coauthors...

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Source: Vaccine Weekly (2003-06-11)

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