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Tuberculosis Vaccine

Single dose of DNA vaccine protects mice against tuberculosis

Published in Vaccine Weekly, June 11th, 2003

A single dose of a vaccine based on DNA encoding mycobacterial hsp65 protein plus TDM-loaded PLGA microspheres protected mice against a virulent strain of Mycobacterium tuberculosis.

"The high incidence of tuberculosis around the world and the inability of BCG to protect certain populations clearly indicate that an improved vaccine against tuberculosis is needed. A single antigen, the mycobacterial heat shock protein hsp65, is sufficient to protect BALB/c mice against challenge infection when administered as DNA vaccine in a three-dose-based schedule," scientists in Brazil report.

"In order to simplify the vaccination schedule, we...

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