Liposome-Delivered Therapy
Hepatic targeting can be achieved by mannosylation and uptake rate by PEGylation
Published in Vaccine Weekly, June 18th, 2003
According to recent research from Japan, "To achieve a sustained and targeted delivery of liposomes to liver nonparenchymal cells, we modified distearoyl phosphatidylcholine and cholesterol liposomes (DSPC/Chol liposomes) with a mannosylated cholesterol derivative (Man-C4-Chol), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-polyethylene glycol (PEG-DSPE).
"Each liposome formulation was adjusted to an approximate size of 70-90 nm, labelled with [H-3]cholesteryl hexadecyl ether, and injected intravenously into mice, to investigate the tissue distribution...
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Source: Vaccine Weekly (2003-06-18)
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