Dengue Fever

Dengue virus NS1, NS2A, NS3, and NS5 mutant proteins restrict replication

Published in Vaccine Weekly, July 9th, 2003

Temperature-sensitive mutations in the genes encoding the NS1, NS2A, NS3, and NS5 nonstructural proteins of dengue virus type 4 restricted replication in the brains of mice.

"Using reverse genetics, it is possible to readily add well-defined attenuating mutations to the genome of wild type or incompletely attenuated dengue (DEN) viruses to generate vaccine candidates that exhibit the desired balance between attenuation and immunogenicity," scientists in the United States report.

"Here, we describe the identification of eight temperature sensitive missense mutations distributed in four non-structural protein genes that specify a 60- to 10,000-fold...

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Source: Vaccine Weekly (2003-07-09)

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