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Cancer Vaccine

Dendritic cell vaccine elicits clinical responses in renal cancer patients

Published in Vaccine Weekly, July 9th, 2003

A tumor RNA-transfected dendritic cell vaccine elicited clinical responses in renal cancer patients.

According to recent research from the United States, "Autologous dendritic cells transfected with total renal tumor RNA have been shown to be potent stimulators of CTLs and antitumor immunity in vitro. A Phase I trial was conducted to evaluate this strategy for feasibility, safety, and efficacy to induce tumor-specific T-cell responses in subjects with metastatic renal cell carcinoma."

"Renal tumor RNA-transfected dendritic cells were administered to 10 evaluable study patients with no evidence of dose-limiting toxicity or vaccine-related adverse...

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