Vaccine Adjuvant

Adjuvants interleukin-12 and cholera toxin enhance immunity to HIV-1

Published in Vaccine Weekly, July 9th, 2003

Interleukin-12 and cholera toxin subunit B act as adjuvants to enhance mucosal and systemic immunity to human immunodeficiency virus type 1 glycoproteins.

According to recent research published in the Journal of Virology, "We have investigated the induction of protective mucosal immunity to human immunodeficiency virus type 1 (HIV-1) isolate 89.6 by intranasal (i.n.) immunization of mice with gp120 and gp140 together with interleukin-12 (IL-12) and cholera toxin subunit B (CTB) as adjuvants."

"It was found that both IL-12 and CTB were required to elicit mucosal antibody responses and that i.n. immunization resulted in increased total,...

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Source: Vaccine Weekly (2003-07-09)

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