Creutzfeldt-Jakob Disease
Brain innoculation with attenuated prions protects indefinitely from virulence
Published in Vaccine Weekly, July 23rd, 2003
"We previously showed that intracerebral (ic) inoculation of the attenuated SY strain of Creutzfeldt-Jakob disease in mice could delay clinical signs and widespread neuropathology evoked by subsequent ic challenge with the more virulent FU strain. Using lower doses of SY and FU ic, we here demonstrate that mice can be protected well into old age without demonstrable neuropathology or pathologic prion protein (PrP-res). In contrast, the parallel FU-only controls became terminally diseased,"...
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Source: Vaccine Weekly (2003-07-23)
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