HIV/AIDS Vaccine

DNA priming improves HSV-1 amplicon-induced T-cell responses

Published in Vaccine Weekly, July 23rd, 2003

by Michael Greer, senior medical writer - DNA priming enhances the performance of an HIV vaccine based on herpes simplex virus particles, researchers in the United States say.

"A single inoculation of herpes simplex virus type-1 (HSV-1) amplicon vectors encoding human immunodeficiency virus type-1 gp120 (HSV:gp120) results in robust, specific immune responses to gp120," explained Xiuqing Wang and colleagues at the University of Rochester Medical Center in Rochester, New York and the University of California at Davis.

Priming with amplicon plasmid DNA significantly augmented the cellular immune activity elicited by HSV:gp120 vaccination, Wang and...

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Source: Vaccine Weekly (2003-07-23)

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