HIV/AIDS Vaccine

Chimeric influenza HA/SHIV virus-like particles show promise for mucosal immunization

Published in Vaccine Weekly, July 30th, 2003

by Michael Greer, senior medical writer - Researchers in Texas have developed a novel technique for mucosal immunization against HIV infection.

"To enhance mucosal immune responses using simian-human immunodeficiency virus-like particles (SHIV VLPs) as a mucosal HIV vaccine," Qizhi Yao and colleagues at Baylor College of Medicine in Houston "produced phenotypically mixed, chimeric influenza HA/SHIV 89.6 VLPs and used them to immunize C57B/6J mice intranasally."

Humoral and cellular mucosal immune activity induced by chimeric VLPs was significantly more robust than that elicited by unmodified SHIV particles, Yao and coauthors found.

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Source: Vaccine Weekly (2003-07-30)

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