Immunology

Francisella novicida LPS more immunogenic than F. tularensis LPS

Published in Vaccine Weekly, July 30th, 2003

Francisella novicida lipopolysaccharide (LPS) has greater immunobiological activity in mice than F. tularensis LPS, and contributes to F. novicida murine pathogenesis.

"To further understand the role of LPS in the pathogenesis of Francisella infection, we characterized murine infection with F. novicida, and compared immunobiological activities of F. novicida LPS and the LPS from F. tularensis live vaccine strain (LVS)." researchers in the United States and Canada report.

"F. novicida had a lower intradermal LD₅₀ in BALB/cByJ mice than F. tularensis LVS, and mice given a lethal...

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Source: Vaccine Weekly (2003-07-30)

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