Pneumococcal Vaccine

DNA vaccine with pneumococcal surface protein A elicits immune responses

Published in Vaccine Weekly, August 6th, 2003

A DNA vaccine containing pneumococcal surface protein A elicited protective humoral and cellular immune responses.

"Streptococcus pneumoniae is a major public health problem and new strategies for the development of cost-effective alternative vaccines are important. The use of protein antigens such as PspA (pneumococcal surface protein A) is a promising approach to increase coverage at reduced costs. We have previously described the induction of a strong antibody response by a DNA vaccine expressing a C-terminal fragment of PspA," scientists in Brazil report.

"Fusion of this fragment with the cytoplasmic variant of SV40 large T-antigen (CT-Ag)...

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Source: Vaccine Weekly (2003-08-06)

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