Rotavirus Vaccine

Rotavirus protein NSP4 induces antibody responses during natural infection

Published in Vaccine Weekly, August 6th, 2003

Rotavirus nonstructural protein NSP4 induced heterotypic antibody responses during natural infection in children.

According to recent research from India, "Seroconversion of immunoglobulin A (IgA) and immunoglobulin G (IgG) ({{>=}}fourfold rise) to rotavirus nonstructural protein 4 (NSP4) was determined, by use of enzyme-linked immunosorbent assay with fusion proteins glutathione S-transferase (GST)-NSP4 from strains SA11 (A), 116E (B), and RRV (C), in 40 children with acute rotavirus gastroenteritis and in 30 with the same disease due to other pathogens."

"The IgG seroconversion rates in the rotavirus group were 67.5%, 70%, and 60% when...

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Source: Vaccine Weekly (2003-08-06)

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