Cancer Vaccine

Naked plasmid DNA injection into solid tumors of mice characterized

Published in Vaccine Weekly, August 6th, 2003

A team of researchers in Japan has characterized the disposition and gene expression in solid tumors and skeletal muscle after direct injection of naked plasmid DNA in mice.

"Previous studies have suggested that direct injection of naked plasmid DNA (pDNA) into solid tumors can be a useful method for in vivo gene transfer into tumor cells. To gain more insight into this approach, we studied the disposition and gene expression characteristics of naked pDNA after intratumoral injection by direct comparison with those after intramuscular injection in mice," scientists writing in the Journal of Pharmaceutical Sciences report.

"pDNA encoding...

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Source: Vaccine Weekly (2003-08-06)

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