HIV/AIDS Vaccine
Lipopeptide MALP-2 effective adjuvant for mucosal delivery of HIV-1 protein
Published in Vaccine Weekly, August 27th, 2003
"A major requirement for HIV/AIDS research is the development of a mucosal vaccine that stimulates humoral and cell-mediated immune responses at systemic and mucosal levels, thereby blocking virus replication at the entry port. Thus, a vaccine prototype based on biologically active HIV-1 Tat protein as antigen and the synthetic lipopeptide, macrophage-activating lipopeptide-2 (MALP-2), as a mucosal adjuvant was developed," scientists writing in the European Journal of Immunology report.
"Intranasal administration to mice stimulated systemic and...
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Source: Vaccine Weekly (2003-08-27)
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