T-Cell Epitopes
Proteasomal cleavage sites of proteins for cytotoxic T cells may soon be fully predictable
Published in Vaccine Weekly, September 3rd, 2003
According to recent research published in the journal International Immunology, "The proteasome plays an essential role in the immune responses of vertebrates. By degrading intercellular proteins from self and non-self, the proteasome produces the majority of the peptides that are presented to cytotoxic T cells (CTL).
"There is accumulating evidence that the C-terminal, in particular, of CTL epitopes is cleaved precisely by the proteasome, whereas the N-terminal is produced with...
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Source: Vaccine Weekly (2003-09-03)
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