Vaccine Development
Transcription factor Fos-related antigen 1 targets breast cancer activity
Published in Vaccine Weekly, September 17th, 2003
"Protection against breast cancer was achieved with a DNA vaccine against murine transcription factor Fos-related antigen 1, which is overexpressed in aggressively proliferating D2F2 murine breast carcinoma," scientists in the United States report.
"Growth of primary subcutaneous tumor and dissemination of pulmonary metastases was markedly suppressed by this oral DNA vaccine, carried by attenuated Salmonella typhimurium, encoding murine Fos-related antigen 1, fused with mutant polyubiquitin, and cotransformed with secretory murine IL-18. The life span of 60% of...
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Source: Vaccine Weekly (2003-09-17)
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