Cancer Vaccine

All-trans-retinoic acid improves effect of tumor vaccination

Published in Vaccine Weekly, October 1st, 2003

All-trans-retinoic acid eliminates immature myeloid cells from tumor-bearing mice and improves the effect of vaccination.

"Tumor-induced immunosuppression is one of the crucial mechanisms of tumor evasion of immune surveillance. It contributes greatly to the failure of cancer vaccines. Immature myeloid cells (ImCs) play an important role in tumor-induced immunosuppression," scientists in the United States report.

"These cells accumulate in large numbers in tumor-bearing hosts and directly inhibit T-cell functions via various mechanisms," stated Sergei Kusmartsev and colleagues at the University of South Florida. "In this study, we tried to eliminate...

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Source: Vaccine Weekly (2003-10-01)

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