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Cancer Vaccine

Carbohydrate-specific antibodies make potential cancer vaccine for human use

Published in Vaccine Weekly, October 15th, 2003

Induction of carbohydrate-specific antibodies in HLA-DR transgenic mice by a synthetic glycopeptide is a potential cancer vaccine in humans.

"Over the last few years, anticancer immunotherapy has emerged as a new exciting area for controlling tumors. In particular, vaccination using synthetic tumor-associated antigens (TAA), such as carbohydrate antigens hold promise for generating a specific antitumor response by targeting the immune system to cancer cells. However, development of synthetic vaccines for human use is hampered by the extreme polymorphism of human leukocyte-associated antigens (HLA)," researchers in France and the United States report.

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