Human Papillomavirus
HPV type 16 E5 protein is potential vaccine target
Published in Vaccine Weekly, October 15th, 2003
According to a study from Taiwan, "Human papillomavirus type 16 (HPV-16) E5 protein, along with the more publicized E6 and E7 proteins of this virus, has been found to be oncogenic. E5 is a highly hydrophobic membrane-bound protein of 83 amino acids associated with the Golgi apparatus, endoplasmic reticulum, and nuclear membrane in infected cells."
"E5 can activate epidermal growth factor receptor (EGFR) through binding to the 16-kD subunit of protein pump ATPase leading to a reduced downregulation of EGFR receptors," stated T.-C. Tsai and S.-L. Chen at the National Defense...
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Source: Vaccine Weekly (2003-10-15)
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