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Syphilis

 Treponema pallidum repeat protein K antibodies protect against syphilis

Published in Vaccine Weekly, November 26th, 2003

Protection against syphilis correlates with specificity of antibodies to the variable regions of Treponema pallidum repeat protein K.

"Syphilis has been recognized as a disease since the late 1400s, yet there is no practical vaccine available. One impediment to the development of a vaccine is the lack of understanding of multiple re-infections in humans despite the development of robust immune responses during the first episode," scientists in the United States report.

"It has been shown that the Treponema pallidum repeat protein K (TprK) differs in seven discrete variable (V) regions in isolates and that the antibody response during...

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