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DNA Vaccine

DNA vaccine induces protective capsular polysaccharide antibody response

Published in Vaccine Weekly, December 3rd, 2003

A multi-epitope DNA vaccine encoding a peptide mimic of meningococcal serogroup C capsular polysaccharide induced a protective capsular polysaccharide antibody response.

According to a study from the United States, "Systemic infection by encapsulated organisms, such as Neisseria meningitidis, is a major cause of morbidity and mortality worldwide, especially in individuals less than two years of age. Antibodies directed at the capsular polysaccharide are shown to be protective against disease by inducing complement-dependent bactericidal activity. The current polysaccharide vaccine has been shown to be poorly immunogenic in high-risk groups and this is probably...

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