Vaccine Adjuvant
Natural antibodies and complement are endogenous adjuvants for vaccines
Published in Vaccine Weekly, December 3rd, 2003
"CD8+ T cells are essential for long-term, vaccine-induced resistance against intracellular pathogens. Here we show that natural antibodies, acting in concert with complement, are endogenous adjuvants for the generation of protective CD8+ T cells after vaccination against visceral leishmaniasis. IL-4 was crucial for the priming of vaccine-specific CD8+ T cells, and we defined the primary source of IL-4 as a CD11b+CD11clo phagocyte," investigators in England report.
"IL-4 secretion was not observed in antibody-deficient mice and could be...
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Source: Vaccine Weekly (2003-12-03)
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