Chagas Disease

Trypanosoma cruzi antigens elicit strong humoral immune response in mice

Published in Vaccine Weekly, December 3rd, 2003

Immunization with the cytoplasmic repetitive antigen and flagellar repetitive antigen of Trypanosoma cruzi elicited a strong humoral immune response in mice.

According to recent research published in the journal Memorias Do Instituto Oswaldo Cruz, "In the present report we analyzed the levels of IgG1, IgG2a, IgG2b, and IgG3 isotypes from BALB/c mice immunized with cytoplasmic repetitive antigen (CRA), and flagellar repetitive antigen (FRA) of Trypanosoma cruzi. The immunization was done by subcutaneous route three times (20 days apart) and the analysis was performed 14 days after each treatment."

"CRA-immunized mice produced high...

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Source: Vaccine Weekly (2003-12-03)

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