HIV/AIDS Therapy

Early SHIV control in monkeys causes long-lasting asymptomatic outcomes

Published in Vaccine Weekly, December 10th, 2003

Early control of highly pathogenic simian immunodeficiency virus/human immunodeficiency virus (SHIV) chimeric virus infections in rhesus monkeys usually results in long-lasting asymptomatic clinical outcomes.

"In contrast to simian immunodeficiency viruses (SIVs), which induce immunodeficiency over a one- to two-year period, highly pathogenic simian-human immunodeficiency viruses (SHIVs) cause an irreversible and systemic depletion of CD4+ T lymphocytes in macaque monkeys within weeks of inoculation. Nonetheless, the seemingly more aggressive SHIVs have proven to be easier to control by the same vaccine regimens that fail to contain SIV," scientists in the United States...

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Source: Vaccine Weekly (2003-12-10)

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