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Malaria Vaccine

Crossreactive antibodies against Plasmodium protein induced

Published in Vaccine Weekly, January 7th, 2004

Researchers have reported the induction of crossreactive antibodies to Plasmodium falciparum variant protein.

"The variant antigen Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), present on the surface of P. falciparum-parasitized erythrocytes (PE), plays a central role in naturally acquired immunity, although antibodies to PfEMP1 are predominantly variant specific. To overcome this major limitation for vaccine development, we immunized mice with three cysteine-rich interdomain 1 (CIDR1) domains of PfEMP1 that have the critical function of binding the PE to CD36 on endothelium and thus preventing spleen-dependent killing of the...

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