Antimicrobial Antibodies

Activated gamma delta T cells go to lymph nodes; increase antibody production

Published in Vaccine Weekly, January 14th, 2004

TCR-triggered gamma delta T cells migrate to lymph nodes; produce costimulatory molecules that enhance B cell antibody production.

"Gammadelta T cells are inadequately defined both in terms of their migration potential and contribution to antimicrobial immunity. We examine the migration profile of human blood gammadelta T cells and related cell lines and correlate these findings with their distribution in secondary lymphoid tissues and their function in B cell cocultures," investigators in Switzerland report.

"We find that resting gammadelta T cells are characterized by an inflammatory migration program similar to cells of the innate immune system....

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Source: Vaccine Weekly (2004-01-14)

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