Immunology
Hepatitis C virus NS4 uses subversive tactics to thwart Th1 response
Published in Vaccine Weekly, February 11th, 2004
According to recent research published in the European Journal of Immunology, "the majority of hepatitis C virus (HCV) infections become chronic, despite the presence of HCV-specific cellular and humoral immune responses. We have previously suggested that interleukin (IL)-10-secreting antigen-specific regulatory T cells may contribute to viral persistence, and demonstrate here that peripheral blood mononuclear cells (PBMC) from chronically HCV-infected patients secrete IL-10, but not IFN-gamma, in response to HCV nonstructural protein 4 (NS4). A neutralizing anti-IL-10 antibody restored this...
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Source: Vaccine Weekly (2004-02-11)
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