Cancer Vaccine

DNA induces T helper type 1-mediated responses in antigen-primed mice

Published in Vaccine Weekly, February 18th, 2004

Anti-CD3 single-chain Fv/interleukin-18 fusion DNA induced T helper type 1-mediated immune responses in antigen-primed mice.

According to recent research published in the journal Immunology, "Two types of T helper (Th) cells, Th1 and Th2, play different roles in protection and immunopathology. The Th1 cell-mediated immune response plays an important role in inducing the host defense against intracellular bacteria and also in cancer immunotherapy. To effectively induce Th1 immune responses, we constructed a mammalian expression plasmid (pAnti-CD3sFv/IL-18) carrying a fusion gene in which anti-CD3 single-chain Fv (sFv) cDNA, the smallest unit of antibody...

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Source: Vaccine Weekly (2004-02-18)

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