Development on schistosomiasis vaccines stalled

"While there are many challenges in vaccine development, none is greater than that of developing vaccines against large metazoan parasites such as schistosomes, the parasitic worms that are responsible for schistosomiasis. Initial optimism stemming from the identification of the first vaccine candidate antigens that gave protection in animals has been dashed by the failure, as yet, of any of the vaccine candidate antigens to enter Phase III clinical trials," researchers in Scotland report.

"Now, despite an improved understanding of the biology of the parasites and of the immune responses they...

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